Application of the Integrated Supercritical Fluid Extraction–Impregnation Process (SFE-SSI) for Development of Materials with Antiviral Properties

The integrated supercritical fluid extraction–impregnation process (SFE-SSI) was performed to fabricate material with antiviral properties against the herpes simplex virus (HSV). Cotton gauze and starch/chitosan polymer films (SCF) were impregnated components extracted from Melissa officinalis at 10 MPa 40 °C using a green medium, carbon dioxide (scCO2). influences of processing mode regarding flow through system, mass ratio plant solid carrier, on impregnation yield M. extract studied. results revealed that introduction fresh amount CO2 into system enabled highest 2.24% for cotton 8.71% SCF. presence surface both gaze SCF confirmed by FTIR GC analyses after re-extraction samples. materials showed strong inhibitory effect Bovine herpesvirus type 1 (BHV-1).